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Antiparasitic Activities of Compounds Isolated from Aspergillus fumigatus Strain Discovered in Northcentral Nigeria

Authors: Diyaolu, OA; Preet, G; Fagbemi, AA; Annang, F; Perez-Moreno, G; Bosch-Navarrete, C; Adebisi, OO; Oluwabusola, ET; Milne, BF; Jaspars, M; Ebel, R

Ref.: Antibiotics 12(1), 109 (2023)

Abstract: In this study, we explored a fungal strain UIAU-3F identified as Aspergillus fumigatus isolated from soil samples collected from the River Oyun in Kwara State, Nigeria. In order to explore its chemical diversity, the fungal strain UIAU-3F was cultured in three different fermentation media, which resulted in different chemical profiles, evidenced by LC-ESI-MS-based metabolomics and multivariate analysis. The methanolic extract afforded two known compounds, fumitremorgin C (1) and pseurotin D (2). The in vitro antiparasitic assays of 1 against Trypanosoma cruzi and Plasmodium falciparum showed moderate activity with IC50 values of 9.6 mu M and 2.3 mu M, respectively, while 2 displayed IC50 values > 50 mu M. Molecular docking analysis was performed on major protein targets to better understand the potential mechanism of the antitrypanosomal and antiplasmodial activities of the two known compounds.

DOI: 10.3390/antibiotics12010109

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