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CoFe2O4 spinel ferrite studies on permanent magnet application and cytotoxic effects on breast and prostate cancer cell lines
Authors: Benali, A; Saher, L; Bejar, M; Dhahri, E; Graca, MFP; Valente, MA; Sanguino, P; Helguero, LA; Bachari, K; Silva, AMS; Costa, BFO
Ref.: J. Mater. Sci.: Mater. Electron. 34(1), 53 (2023)
Abstract: In the present research work, the sol-gel auto-combustion preparation method using two different fuels agents (citric acid and glycine) was used to synthesize CoFe2O4 nanoparticles. The structural and morphological studies were performed to confirm the ability to obtain a pure cubic spinel phase with a particle size < 100 nm. The particle size effects on structural, Raman and magnetic properties of the CFO was studied to confirm that the glycine fuel decreased the particle size and the saturation magnetization. The CoFe2O4 nanoparticles were found to exhibit a considerable value of maximum energy product (BH)(max), which makes them good candidate for permanent magnet applications. Notably, the cytotoxic activity of both prepared compounds against two different human breast cancer cells (T47-D and MDA-MB-231) and one prostate cancer cell (PC3) were evaluated. Both C1 and C2 compounds are quite cytotoxic against the human breast and prostate cancer cells and the C2 with lower particle size was found to have the higher cytotoxic potency (minimum viability values) with 49%, 39% and 19% in MDA-MB-231, PC3 and T47-D cancer cells, respectively. The cytotoxicity against normal human cells was found to be lower than 3% even for high C2 particle concentrations, reflecting the human-safe-and-friendly nature of the CoFe2O4.
