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Enhancing Norfloxacin´s solubility: Development and characterization of new solid-state forms with p-aminobenzoic acid
Authors: Costa, G.D.; Ferreira, P.O.; Baptista, J.A.; Silva, PSP; Castro, R.A.E.; Caires, F.J.; Eusébio, M.E.S.
Ref.: J. Solid State Chem. 353, 125698 (2026)
Abstract: This study reports, for the first time, the formation of four new multicomponent solid forms of norfloxacin (NOR) with p-aminobenzoic acid (PABA). Among them, the ethanol-assisted grinding product (NPL) and the heattreated salt (NPH) exhibited a remarkable sevenfold increase in solubility compared to commercial NOR. These materials were prepared by mechanochemical and slurry methods and characterized by thermal analysis, X-ray diffraction, and spectroscopic techniques. Mechanochemistry proved to be a sustainable approach, avoiding large amounts of solvent. Furthermore, conditions for the reproducible scale-up production of NPH with high purity were successfully established. These findings highlight the potential of solid-state modulation with PABA to significantly improve the pharmaceutical performance of NOR and provide viable routes for industrial applications.
